Hyperpolarized [1-13C] pyruvate Magnetic Resonance Spectroscopic Imaging (MRSl) identifies pancreatic cancer subtypes in mice

Irina Heid1, Moritz Mayer1, Katja Peschke2, Geoffrey J. Topping3, Katja Steiger1, Martin Grashei3, Maximilian Aigner3, Marija Trajkovic-Arsic5, Maximilian Reichert2, Franz Schilling3, Rickmer Braren1,6

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Research Area C6


Pancreatic ductal adenocareinoma (PDAC) is a heterogeneous disease with poor prognosis in need of non-invasive subtype biomarkers. Two main transcriptional subtypes have been identified: Classical and quasi-mesenchymal (QM)1. The QM subtype is associated with increased glucose metabolism2,3, high expression
of monocarboxylate transporter 4 (MCTA)4,5 and can possibly be detected by metabolic imaging. We here present hyperpolarized (HP)-[1-13C]pyruvate chemical-shift imaging (CS1) in combination with Diffusion-Weighted Imaging (DWI) for QM subtype prediction in endogenous murine (m)PDAC.